Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase
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چکیده
منابع مشابه
Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase
Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with microaerophilic protist parasites, including Entamoeba histolytica. For activation, the drug must be chemically reduced, but little is known about the targets of the active metabolites. Applying two-dimensional gel electrophoresis and mass spectrometry, we searched for prot...
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It has been suggested that two distinct species exist within what was originally known as Entamoeba histolytica and E. dispar. These are Entamoeba dispar for the nonpathogenic and E. histolytica for the pathogenic fonn. Differentiation of these two organisms is of great clinical importance since they are morphologically indistinguishable and both fonns can infect the human intestinal cavity...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2007
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0050211